Pharmacological actions of RU Mifepristone:
RU is a preparation contains mifepristone primarily which is a progesterone antagonist. Progesterone is a female pregnancy hormone that supports development of pregnancy. Mifepristone shows its activity by inhibiting the functions of progesterone. Progesterone is a female hormone required for the continuation of pregnancy. It modifies the uterine lining for the development of fetus. Mifepristone binds on the progesterone receptors and inhibits its actions. It reduces the progesterone concentration due to that uterine lining began to shed off and fetus becomes died.
Administration method of mifepristone:
Mifepristone 200mg is administered orally with sufficient water. Heavy bleeding with clots confirms the starting of abortion and its completion indicates the emptying of the womb. After 14days woman must go to doctor for clinical examination and must go for ultrasound for confirmation of abortion. Woman is advised to take two pills of misoprostol 200mcg either orally or intravaginally if abortion is not found to be complete or bleeding didn’t start with mifepristone. After some days, it is advised to revisit the doctor.
Nausea followed by diarrhoea, vomiting, abdominal cramps, pelvic pain, and stomach upsets; GI disturbances etc are side effects experienced by the users of mifepristone.
Avoid using mifepristone, in case of anaemia, bleeding disorders, and heart and kidney diseases, If IUD is placed then it is advisable to remove that before using mifepristone. Take nutrients enrich diet after abortion and avoid uplifting heavy material. Intake of alcohol is not permitted during and after abortion process. Sensual activities are not allowed after some days of abortion.
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